October 4, 2023 at 6:53 pm #1857AKN AdminKeymaster
A postdoctoral position is available in Lee lab (Unit on Functional Neural Circuits).
My lab aims to understand the organization of neural circuits that enable corticocortical communication and support the computations of dynamic interactions between sensory and behavioral functions. To comprehend how the neocortex integrates and contextually computes relevant incoming information, a mechanistic understanding of the recruitment and role of the various cellular and circuit elements within the corticocortical communication is imperative. Using mouse whisker-dependent sensorimotor system, we are addressing this question with a research program that has four themes.
1. What are the circuits underlying local and long-range cortical communication?
2. What is the behavior relevance of these circuits?
3. What do these circuits compute?
4. What are the developmental specificity and plasticity of these circuits?
We are looking for highly talented and motivated postdoctoral fellows who have a MD/PhD or PhD in Neuroscience or related disciplines and who have a record of research productivity. We are particularly interested in candidates who have strong quantitative and programming skills and experience in at least one of the following tools; imaging, electrophysiology (in vitro and/or in vivo), and mouse behavior. Scientific creativity and communication skills are also important as the candidates will work both independently and as part of a team. Salary will be commensurate with education and experience.
Start date: flexible
From Lee Lab
Inacio AR, Lam KC, Zhao Y, Pereira F, Gerfen CR, Lee S. Distinct brain-wide presynaptic networks underlie the functional identity of individual cortical neurons bioRxiv 2023.05.25.542329;doi:https://doi.org/10.1101/2023.05.25.542329 (under revision, Nature)
Rhodes CT, Asokumar D, Sohn M, Naskar S, Elisha L, Stevenson P, Lee DR, Zhang Y, Rocha PP, Dale RK, Lee S, Petros TJ. Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles
bioRxiv 2023.09.06.556544; doi: https://doi.org/10.1101/2023.09.06.556544 (under review)
Naskar S, Inacio AR, Stevenson P, Qi J, Lee S. Development of cortical disinhibitory circuit (In preparation)
Naskar S, Stevenson P, Ye C, Qi J, Lee S. Reduction of SynGAP1 in cortical Parvalbumin-positive GABAergic neurons impairs long-range cortico-cortical connectivity. (In preparation)
Qi J, Ye C, Naskar S, Inácio AR, Lee S. Posteromedial thalamic nucleus activity significantly contributes to perceptual discrimination. PLoS Biol. 2022 Nov 28;20(11):e3001896. PMID: 36441759
Jung WB, Jiang H, Lee S, Kim SG. Dissection of brain-wide resting-state and functional somatosensory circuits by fMRI with optogenetic silencing. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2113313119. PMID: 35042795
Zagha E, Erlich JC, Lee S, Lur G, O’Connor DH, Steinmetz NA, Stringer C, Yang HJ. The importance of accounting for movement when relating neuronal activity to sensory and cognitive processes. Journal of Neuroscience. 2022 Jan 6:JN-TS-1919-21. PMID: 35027407
Naskar S, Qi J, Pereira F, Gerfen CR and Lee S. Cell-type-specific recruitment of GABAergic interneurons in the primary somatosensory cortex by long-range inputs. Cell Reports. 2021 Feb 23;34(8):108774. doi: 10.1016/j.celrep.2021.108774, PMID: 33626343
From previous works
He M, Tucciarone J, Lee S, Nigro MJ, Kim Y, Levine JM, Kelly SM, Krugikov I, Wu P, Chen Y, Gong L, Hou Y, Osten P, Rudy B, Huang ZJ. Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex. Neuron 91(6):1228-43, 2016. PMID: 27618674
Tremblay R, Lee S, Rudy B. GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits. Neuron 91(2):260-92, 2016. PMID: 27477017
Lee S, Kruglikov I, Huang J, Fishell G, Rudy B. A disinhibitory circuit mediates motor integration in the somatosensory cortex. Nature Neuroscience 16(11):1662-70, 2013. PMID: 24097044
Rudy B, FIshell G, Lee S, Hjerling-Leffler J. Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons. Dev. Neurobiol. 71(1):45-61, 2011. PMID: 21154909
Lee S, Hjerling-Leffler J, Zagha E, Fishell G, Rudy B. The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors. Journal of Neuroscience 30(50):16796-808, 2010. PMID: 21159951
Lee S, Carvell G, Simons DJ. Motor modulation of afferent somatosensory circuits. Nature Neuroscience 11(12):1430-8, 2008. PMID: 19011625
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